Cardiovascular CV disease fatality rates are higher for women compared with men with diabetes despite lower rates of obstructive coronary artery disease CAD. Impaired coronary flow reserve CFR , the ratio of adenosine-stimulated to rest myocardial blood flow MBF , is an indicator of coronary microvascular dysfunction and predicts major adverse CV events. We performed a post hoc analysis to determine whether there was a sex disparity in coronary microvascular dysfunction among 46 men and 27 women with well-controlled type 2 diabetes and without clinical evidence of obstructive CAD. In addition, rest MBF was positively correlated with worse diastolic function in women. We previously showed that mineralocorticoid blockade improved CFR in men and women with type 2 diabetes, implicating aldosterone in the pathophysiology of coronary microvascular dysfunction.
Ep1: Gender, Sex & Sexuality
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Sex Differences in Coronary Microvascular Function in Individuals With Type 2 Diabetes
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